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The Lead

Dengue fever outbreak infects thousands in war-torn Yemen

June 18, 2015 | by AHMED AL-HAJ, Associated Press | Comments

Mountains of uncollected garbage, sewage and heat have contributed to the spread of the disease.

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Chitosan-coated, chemotherapy packed nanoparticles may target cancer stem cells

June 30, 2015 12:41 pm | by Ohio State University Wexner Medical Center | Comments

Nanoparticles packed with a clinically used chemotherapy drug and coated with an oligosaccharide derived from the carapace of crustaceans might effectively target and kill cancer stem-like cells, according to a recent study....

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Draft guidance helps designers modify ongoing clinical trials

June 30, 2015 12:24 pm | by Elizabeth Orr, FDA | Comments

Sponsors considering whether to use an adaptive clinical trial design should select a number of realistic scenarios and determine how likely each is to succeed with a particular adaptive design, the FDA says.

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21st Century Cures Act sails through House committee

June 30, 2015 12:15 pm | by Elizabeth Orr, FDA | Comments

The ayes had it with the House Energy & Commerce Committee May 21, with all 51 members voting to pass the latest version of the 21st Century Cures Act. The bill, H.R. 6, released May 19, encourages greater use of observational studies....

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The first ever virtual diagnostic testing for healthcare consumers

June 30, 2015 12:12 pm | by BUSINESS WIRE | Comments

HealthTap and Quest Diagnostics announced a collaboration that will enable doctors to order diagnostic testing services for patients through HealthTap’s comprehensive virtual care platform. This is the first ever partnership between a major national medical laboratory provider ...

Pinaverium shows promising results for treatment of irritable bowel syndrome

June 30, 2015 12:07 pm | by American Gastroenterological Association | Comments

Pinaverium offers quick and effective relief of irritable bowel syndrome (IBS) symptoms, according to clinical trial results published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

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Ritter Pharmaceuticals, Inc. announces closing of $20,000,000 IPO

June 30, 2015 11:59 am | by BUSINESS WIRE | Comments

Ritter Pharmaceuticals, Inc., a pharmaceutical company developing novel therapeutic products that modulate the human gut microbiome to treat gastrointestinal diseases with its lead product, RP-G28, being developed for the treatment of lactose intolerance ...

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FDA issues the Drug Supply Chain Security Act implementation

June 30, 2015 11:31 am | Comments

The Drug Supply Chain Security Act (DSCSA) requires dispensers, which primarily include pharmacies, to comply with new requirements related to product tracing beginning July 1, 2015. Today FDA issued the ...

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Capsugel unveils new spray-dried dispersion commercial manufacturing facility

June 30, 2015 10:31 am | Capsugel | Comments

Capsugel announced that it has completed construction of a new pharmaceutical spray-dried dispersion (SDD) commercial manufacturing facility at its site in Bend, Ore. The completion represents the final phase of a two-year, $25 million investment....

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PI3K inhibitors may cause cancers to become more aggressive and metastatic

June 30, 2015 9:29 am | by The Wistar Institute | Comments

The enzyme phosphatidylinositol-3 kinase (PI3K) appears to be exploited in almost every type of human cancer, making it the focus of considerable interest as a therapeutic target, with many PI3K-inhibiting drugs currently in various stages of clinical development.

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Experts: California vaccine bill would prevent new outbreaks

June 30, 2015 9:22 am | by JULIA HOROWITZ, Associated Press | Comments

If California's strict school vaccine bill becomes law, experts believe it could help prevent another outbreak like the one that occurred at Disneyland. The bill was introduced after a measles outbreak traced to the theme park in December infected over 100 people....

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New role for Twitter: Early warning system for bad drug interactions

June 30, 2015 9:20 am | by University of Vermont | Comments

A team of scientists has invented a new technique for discovering potentially dangerous drug interactions and unknown side-effects -- before they show up in medical databases, like PubMed, or even before doctors and researchers have heard of them at all.

Global biosimilars market value could hit $55 billion by 2020

June 30, 2015 8:53 am | by GBI Research | Comments

The global biosimilars market value is expected to reach $20 billion by the end of 2015 and could hit $55 billion by 2020, with growth primarily driven by a promising pipeline in active development and government efforts to reduce healthcare spending....

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Using bacterial 'fight clubs' to find new drugs

June 29, 2015 3:15 pm | by Vanderbilt University | Comments

Creating bacterial "fight clubs" is an effective way to find new drugs from natural sources. That is the conclusion of a team of Vanderbilt chemists who have been exploring ways to get bacteria to produce biologically active chemicals....

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Theranos -- a healthcare industry revolution or a marketing phenomenon?

June 29, 2015 2:42 pm | by De Gruyter Open | Comments

The press is hailing it as a revolution in the healthcare industry: The fingerprick test procedure developed by Theranos can assess up to 200 different values from a single drop of blood and show indicators of potential medical conditions.

Major step for implantable drug delivery device

June 29, 2015 10:16 am | by MIT | Comments

An implantable, microchip-based device may soon replace the injections and pills now needed to treat chronic diseases: Earlier this month, MIT spinout Microchips Biotech partnered with a pharmaceutical giant to commercialize its wirelessly controlled ...

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