Pfizer Inc and Drugs for Neglected Diseases
initiative (DND
i) have signed an agreement that is designed to facilitate advancements in the battle against human African trypanosomiasis (HAT), visceral leishmaniasis (VL) and Chagas disease, which afflict vulnerable populations in the developing world. Under the agreement, DNDi will have access to the Pfizer library of novel chemical entities, in order to screen it for compounds that have the potential to be developed into new treatments.
“Despite considerable progress made in recent years, these three diseases continue to take a terrible human toll and represent a significant social burden for developing countries,” said Dr. Manos Perros, vice president and chief scientific officer of antivirals research, Pfizer Global Research & Development. “We are expanding our commitment to the fight against tropical diseases by joining forces with DNDi by sharing our collection of chemical compounds and the knowledge and expertise associated with these chemical entities.”
Under the agreement, scientists in institutes affiliated with DNDi will test at least 150,000 compounds in the Pfizer library against
Trypanosoma brucei, Leishmania donovani and Trypanosoma cruzi, the parasites that cause HAT, VL and Chagas Disease, respectively.
In a process called screening, researchers will seek compounds that show initial activity against the various parasites, and thus might form the basis for novel drug discovery programs to treat the diseases. The screening will be undertaken at the Eskitis Institute for Cell and Molecular Therapies, Griffith University in Brisbane, Australia for HAT and the Institut Pasteur Korea, for VL and Chagas disease.
This collaboration will maximize the chances of identifying attractive starting points for a drug discovery program. “We are confident that the significant resources and expertise that public-private partnerships such as this one bring together, will accelerate and significantly increase the chances of success in the search for effective new drugs against serious infections that disproportionately affect the poor,” said Dr. Sam Azoulay, senior vice president of medical & development, Pfizer Emerging Markets Business Unit.
"This agreement provides us access to a compound library of novel chemical entities that has never been explored for kinetoplastid diseases. This marks an important step towards DND
i’s objective of building a robust portfolio and to feed the research and development pipeline with new promising compounds,” said Dr. Shing Chang, R&D director at DNDi.
About Neglected Diseases
Visceral leishmaniasis (VL), a potentially fatal disease if left untreated, is present in 62 countries, with 200 million people at risk and 500,000 new cases and 51,000 deaths each year. Current therapeutic options for VL are limited as there are significant drawbacks, including method of administration, toxicity, lengthy treatment period, and cost.
Human African trypanosomiasis (HAT, also known as sleeping sickness), is a fatal disease which, if not treated, threatens more than 50 million people in 36 countries and has limited treatment options. Every year 50,000 to 70,000 people are infected and 48,000 die. There is a need for an effective oral drug to treat stage two of the disease when parasites have penetrated the central nervous system.
Chagas disease kills more people in the region every year than any other parasite-born disease, including malaria. Over eight million people are infected with an average of 14,000 deaths per year, and 100 million at risk in 21 countries across Central and South America. Drugs are needed to treat both acute and chronic phases of Chagas disease, as are safer and more effective drugs adapted to patient needs.