The NovaSeptum® AV (Accurate Volume) system is designed to meet the challenges of aseptic and sterile sampling. The NovaSeptum AV system is a closed, accurate sampling system that enables production personnel to obtain small-volume product samples easily and efficiently without the risk of cross contamination. Consecutive individual small-volume samples for immediate in-process testing or distribution to appropriate QC personnel for testing are easily obtained. The ability to obtain the specific sample volumes directly at the bioreactor, eliminates the need to aliquot individual samples in the lab. The elimination of the aliquoting step further reduces the risk of cross contamination as well as potential product waste. The unique syringe design also enables accurate dispensing improving sampling efficiency while reducing potential product waste. The NovaSeptum syringe can also be stored until sample testing is required.