The advantages of prefilled syringes can be further enhanced by reducing the size of the air (gas) bubble inside the syringe or better yet, eliminating it totally. Bubble elimination in a prefilled syringe offers many advantages and after validated studies a method is available to fill syringes without the air bubble. This technology is patented and trademarked as BUBBLE-FREE FILLING®. Prefilled syringes instead of vials have become the container of choice for parenteral drug delivery. The technique of BUBBLE-FREE FILLING® further enhances the benefits of prefilled syringes. The key advantages of prefilled syringes are: safety in administration, ease of use (for both healthcare professionals and end users), reduced risk of contamination, less waste of costly or scarce API, improved dosing accuracy, and improved sterility assurance.