The aseptic ChargePoint high containment split butterfly valve system can be sterilized in place enabling powder transfer without risk of product contamination or operator exposure. The ChargePoint enables products to be transferred in a sterile manner, by creating an intermediate chamber, which can be sterilized before each product transfer. This in situ sterilization capability ensures sterility of the split valve parts when fully docked. The intermediate docking position allows cleaning and irrigation of the intermediate zone with HEPA filtered Nitrogen or air to achieve Grade A/Class 100 environment prior to sterilization with hydrogen peroxide vapor. This cleaning and sterilization cycle enables aseptic product transfers and connections. The combination of decontamination and sterilization results in prevention of endotoxins and minimization of bioburden.