Tools modify the performance of cascade impactors currently specified in USP and Ph.Eur, allowing rapid identification of the fraction of a dose that will be inhaled. Cascade impactors are routinely used for the testing of all inhaled products. cascade impactors that simplify the study of key performance characteristics. Options are available for the Andersen and Next Generation Pharmaceutical Impactors (ACI and NGI) and for the Multi-Stage Liquid Impinger (MSLI). A new exhaust cup allows flow extraction from any stage within the NGI, with the added capability of reintroducing flow further downstream, thereby reducing the number of impactor stages utilised. A new deep cup also allows by-passing of a single stage, the sample simply passing through without impaction. For the ACI a similar effect is achieved by simply omitting stages from the standard stack; the company now supplies modified spring clamps and/or a “Quick-Clamp” that ensure an adequate seal for modified configurations. With respect to the MSLI a four stage option, in addition to the current five stage version, is also available on request. Using these options to coarsen the separation characteristics of the instrument reduces the number of fractions produced and the associated analytical burden. The developer can focus specifically on the fine particle fraction, the fraction that will be inhaled, or whichever size range is of most interest. Rigorous multi-stage cascade impaction provides more detailed information as it is needed.

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Copley Scientific Ltd
Colwick Quays Business Park, Private Rd No 2
Colwick, Nottingham, NG4 2JY