Femur Fracture Risk with Osteoporosis Drugs
FDA has issued updated information on atypical fractures of the femur associated with the use of bisphosphonates to treat osteoporosis. These drugs include Fosamax (alendronate sodium), Actonel (risedronate sodium), Boniva (ibandronate sodium), Atelvia (risedronate sodium), Reclast (zoledronic acid), and their generic equivalents. The femur fractures seen with bisphosphonates have been subtrochanteric and diaphyseal, which are uncommon - accounting for less than one percent of the hip and femur fractures that occur in the population overall. Although it is not clear that the drugs are a direct cause of these unusual fractures, they have mainly been reported in patients taking bisphosphonates.